Dissolution Capsule Sinkers

Floating dosage forms often face challenges in dissolving at a consistent and reproducible rate. Utilizing a sinker with Apparatus 2 ensures that the dosage form remains fixed at a specific point, enhancing reproducibility. Sinkers also help prevent dosage forms from sticking to the sides of the vessel, which can interfere with accurate dissolution testing. Additionally, sinkers are beneficial in disintegration testing to keep floating dosage forms submerged.

Capsule Sinkers

When selecting a sinker, it's important to consider several factors to ensure optimal performance and accurate results. Here are some general guidelines to help you choose the right sinker for your application:

Sinker Size: The sinker should have minimal surface contact with the tablet to avoid affecting the dissolution rate.
Sinker Weight: The weight should be just enough to achieve the desired effect without being excessive.
PTFE Coated Sinkers: Ideal for use with magnetic retrieval systems or when there is a risk of reaction between the steel and the tablet.
Uncoated Sinkers: Made from type 316 stainless steel, these sinkers offer greater durability compared to coated sinkers.
Basket Sinkers: These can be used effectively, but care must be taken to ensure that the tablet's outer coating does not clog the mesh.
Wire Spirals: Should be as wide as practically possible to avoid clogging and ensure smooth operation.

Here is a selection of dissolution sinkers available

• Basket Sinkers
  

Product Name/Part Number	Product Description	Product Link
SI-12-3070	Japanese Pharmacopeia Basket Sinker, 316 SS	Buy Now
SI-12-3062	8 Mesh Sinker Basket with Lid, 316 SS	Buy Now
SI-12-3063	20 Mesh Sinker Basket with Lid, 316 SS	Buy Now
SI-12-3064	20 Mesh Sinker Basket with Lid, 316 SS	Buy Now

• Vertical Sample Holders

Product Name/Part Number	Product Description	Product Link
BK-12-2170	Vertical Sample Holder for Metformin 500mg, 316 SS	Buy Now
BK-12-2165	Vertical Sample Holder for Metformin 500mg, 316 SS	Buy Now